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openprotein-ai

Openprotein Ai · v2 · 9× · naposledy 30. 6. 2026

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PoET-2 is a multimodal protein language model by OpenProtein.AI (NE47 Bio) that learns generative distributions over protein sequences through in-context Learning from sequence and optional structure data. With only 182 million parameters, it achieves performance comparable to trillion-parameter models according to the provider and substantially outperforms larger Foundation Models at a fraction of the computational cost. The model is offered via the OpenProtein.AI web platform and APIs for tasks such as Zero-Shot variant effect prediction and sequence property modeling; code and model weights are available on GitHub/Zenodo for non-commercial purposes.

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Vlastnosti

Deployment ModelCloud platform (web app/API); inference code available for self-hosted Linux/NVIDIA GPU environment via GitHub
Use Case ScopeProtein engineering: zero-shot variant effect prediction, sequence generation, fitness/stability/binding prediction
IntegrationsOpenProtein.AI platform incl. AlphaFold2, ESM2 and Clustal Omega for design & optimization
LicensePoET Non-Commercial Artifacts License (model weights); commercial license available on request from NE47 Bio
PlatformOpenProtein.AI web app and REST/Python API
PriceFree for academic use; commercial use via OpenProtein.AI platform/API (pricing not publicly listed)
Release DateFebruary 11, 2025 (announcement)

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